MDA was first synthesised in 1910 by G. Mannish and W. Jacobson. First human trials for MDA was in 1941 in order to investigate any medicinal qualities for Parkinson’s syndrome, and later if it could be used as an anti-depressant.

On the 8th of January, 1953, the first MDA overdose was recorded during an experiment funded by the U.S army, whom were working on finding a truth serum.

In 1963 and 1964, MDA began to be used by various countercultures, and slowly grew in popularity.

The drug is now scheduled under the Misuse of Drugs act of 1971, as a Class A