There is very little information out there about harm reduction techniques out there as methylone is still a relatively new drug, with little risk information available. For this reason it is highly advised that people start off with very small doses, and do not exceed above 200mg in a session. A large number of people have reported that anything above 180 to 200 mg will increase your heart rate and blood pressure to a very worrying level.
When the product was sold legally, it was advised that one should take half a bottle first (a full bottle was 180mg), and only take the other if you were sure you were ok to do so. It is not advised to mix methylone with alcohol, medicines, or any other drugs.
See our ‘research chemicals’ section for more information on new drugs.