TFMPP interacts with the serotonergic system through 5-ht type 1 and type 2 receptors. It is considered 3 times less potent than MDMA at increasing serotonin by inhibiting its reuptake (see MDMA section for more details on this).

BZP + TFMPP: these two substances seem to work synergistically in the central nervous system. Even at low doses, they increase levels of serotonin and dopamine parallel to each other mimicking the effects seen in MDMA. Some studies have even shown that at higher doses of both drugs, a greater level of dopamine is produced than the drug on its own.